The numbers didn't add up. Over and over, Daniel Yuan, a medical doctor and statistician, couldn't understand the results coming out of the lab, a prestigious facility at Johns Hopkins Medical School funded by millions from the National Institutes of Health. "At first, it was like, 'Okay — but I don't really see it,' " Yuan recalled. "Then it started to smell bad." His suspicions arose as reports of scientific misconduct have become more frequent and critics have questioned the willingness of universities, academic journals and the federal government, which pays for much of the work, to confront the problem.