Vanderbilt University Medical Center is eliminating several hundred more jobs this week as part of its plan to cut up to 1,000 positions by the end of the year. "We've notified the mayor's office and the governor's office of our need to reduce the size of our work force by approximately 1,000 people by the end of the year," said John Howser, spokesman for VUMC. "What's happened here at Vanderbilt is today we've started this action, and several hundred people will be leaving the organization." This latest round of layoffs is part of the Medical Center's plan to cut $250 million from its $3.3 billion operating budget over the next two fiscal years.