An advisory panel to the Centers for Medicare & Medicaid Services (CMS), called to discuss definitions of treatment-resistant depression, met for a day and voted on several points, but ended the meeting without offering such a definition. What the Medicare Evidence Development & Coverage Advisory Committee (MEDCAC) did do was express a high confidence level in certain criteria for treatment-resistant depression (TRD) that, members said, could be used as a research definition and translated to clinical use.