For nearly 2 years, SG2 have advanced the concept of disease-centered Sg2 Systems of CARE as the model of the future for healthcare delivery, says Sg2 Vice President Stephen Jenkins. As health systems are increasingly held accountable for what happens across the continuum, Systems of CARE provide the platform to succeed, clinically, and financially, Jenkins says. Here, Jenkins provides some key ideas of how to build these disease-centered Systems of CARE.