The U.S. Supreme Court will weigh a second major case targeting President Barack Obama's healthcare law on Wednesday when it considers a conservative challenge to tax subsidies critical to the measure's implementation. The case is set for a one-hour oral argument starting just after 10 a.m. (1500 GMT), with a ruling due by the end of June. If a majority of the nine justices rules against the administration, up to 7.5 million people in at least 34 states would lose subsidies that help low- and moderate-income people afford private health insurance, unless Congress or the affected states act immediately.