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The mystery of what's causing young people's cancer leads to the gut

By The Wall Street Journal  
   January 03, 2025

Researchers have identified a focal point for the forces they suspect of driving up cancer cases in young people: the gut. They are searching people’s bodies and childhood histories for culprits. Rates of gastrointestinal cancers among people under 50 are increasing across the globe. In the U.S., colorectal cancer is the leading cause of cancer death in men under 50 and second for women behind breast cancer. Each generation born since the 1950s has had higher risk than the one before. "Everything you can think of that has been introduced in our society since really the 1960s, the post-World War II era, is a potential culprit," said Dr. Marios Giannakis, a gastrointestinal oncologist at the Dana-Farber Cancer Institute in Boston.

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