Silicon Valley has spent years promising to disrupt the $3.5 trillion health-care industry. In 2018, venture investors — from the Bay Area, Boston and elsewhere — poured billions of dollars into the sector, funding start-ups that aim to bring down the costs of care while improving quality and access to the right providers. Some of the hottest trends include virtual care solutions, wearables, medication management apps and new tools that allow physicians to engage with their patients between visits.