Diagnosing heart disease in women is sometimes difficult, but molecular PET and SPECT imagin is beginning to contribute to resolving the problem, writes Johannes Czernin, MD, a professor of Molecular and Medical Pharmacology at UCLA. PET/CT's ability to correct for soft tissue attentuation, and its excellent spatial and temporal resolution allows it to quantify blood flow in the various regions of the heart. With SPECT/CT, appropriate soft-tissue attentuation is now possible, reducing the number of false positive findings, Czernin writes.