Bill Frist is a man driven by challenges. When it comes to healthcare, the bigger the climb, the more Frist is interested. Frist's most ambitious endeavor yet may be Aspire Health, a palliative care physician network for the sickest patients that launches this week in Nashville with the goal of expanding nationwide. It places Frist, who serves as co-founder and chairman, firmly in the business seat of one of health care's biggest challenges: improving care and lowering costs for patients with chronic illnesses.