Up to 400 Novant Health employees – or 2 percent of the hospital system's workforce – will be laid off in coming days as part of a reorganization that began last fall. The changes became public Monday as officials of the Winston-Salem-based system began talking with Charlotte-area employees about potential reassignments as some positions are eliminated. Some changes are effective immediately, but others will be made in the next 45 days. Officials said they could not estimate the impact on the Charlotte market, which includes Presbyterian Medical Center, Charlotte Orthopaedic Hospital, Huntersville Medical Center and Matthews Medical Center as well as numerous physician practices and outpatient centers.