CVS Health, UnitedHealth Group and Cigna are suing the FTC, claiming that the agency's case against drug supply chain middlemen over high insulin prices in the U.S. is unconstitutional. The complaint is the latest move in a bitter legal fight between the three largest PBMs in the U.S. and the FTC. The FTC in September sued CVS's Caremark, Cigna's Express Scripts and UnitedHealth's Optum Rx in the agency's administrative court, accusing those PBMs and other drug middlemen of using a "perverse" rebate system to boost their profits while inflating insulin costs for Americans.