Leader of cancer center works on changes after feedback

Ronald DePinho, the president of the M. D. Anderson Cancer Center, part of the University of Texas, becomes animated when he talks about his ambitious plans in leading the institute's efforts to combat the disease. In two weeks, Dr. DePinho plans to give a public report on the first year's progress of M. D. Anderson's 'moon shots' program. But the tenure of Dr. DePinho, who has been president since 2011 and is the fourth in the institution's 72-year history, has been marked by distractions and growing unease as much as by lofty aspirations.