A new test that requires people to send stool samples in the mail for laboratory analysis is proving nearly as reliable as a colonoscopy in identifying potentially fatal colon cancers. The DNA screening test, invented at the Mayo Clinic, could become an alternative to the colonoscopy — or at least an option for the millions of Americans who ignore their doctors' recommendations because they are squeamish about the rectal exam or concerned about its cost, said Dr. David Ahlquist, a Mayo gastroenterologist and co-inventor of the Cologuard system.