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Novel effort to fight cancer with cancer cells

By The Wall Street Journal  
   January 25, 2011

In an audacious twist on the concept of fighting fire with fire, scientists have developed a provocative strategy of fighting cancer with cancer. Researchers at the Rogosin Institute are taking tumor cells from mice, encapsulating them in beads made from a seaweed-derived sugar called agarose, and implanting them in the abdomen of cancer patients. There, cells in the beads secrete proteins researchers believe could signal a patient's cancer to stop growing, shrink or even die. So far, at least 30 patients have been treated with the cancer beads in an initial human study, and a phase two or intermediate-stage trial has been launched—with the approval of the U.S. Food and Drug Administration—to test the technique in patients with advanced colon, pancreatic and prostate cancers.

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