In contemporary society, we like to talk about thinking outside the box. Sometimes, though, you have to build an entirely new box. Such is the case for children's hospitals working to improve patient safety in their facilities. Since the Institutes of Medicine first published "To Err is Human: Building a Safer Health System," their report on patient safety in 1999, health care has struggled with how best to protect those cared for in our system. Now, 16 years later, the search for how to do just that might be close to finding that elusive treasure.