Welcome to the cloud hospital, where big data takes on mysterious medical conditions

You probably haven't heard of a disease called arterial calcification due to deficiency of the CD73 enzyme, which causes painful calcium buildup in the joints and blood vessels. Discovered in 2011 through the Undiagnosed Disease Program (UDP) at the U.S. National Institutes of Health, only a handful of individuals are believed to suffer from the disease, which is also known as ACDC. For people with obscure conditions, sometimes called mystery diseases, UDP has been a last resort that combines weeklong medical examinations, genetic sequencing, and data analysis in an effort to finally find a diagnosis and treatment for patients who are at wit's end.