For 24 hours these were the side effects Irma Duran went through after her second Pfizer shot. "I had my shot at 10:30 in the morning and then at midnight that's when I woke up. I had a high fever and my bones... It felt like sand paper. Like someone was sanding my bones," said Duran. A University of California San Francisco expert says these side effects after the second COVID-19 shot are normal because the immune response to the second shot is stronger.