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GLP-1s may increase risk of osteoporosis and gout, new research finds

By NBC News  
   March 03, 2026

GLP-1 drugs — including Ozempic and Wegovy — may be tied to a slightly higher risk of osteoporosis and gout, according to research presented Monday at the American Academy of Orthopaedic Surgeons' annual meeting. Dr. John Horneff, an associate professor of orthopedic surgery at the University of Pennsylvania and the lead author of the study, said he began looking into the issue after some patients appeared to develop serious tendon tears after relatively minor injuries. That led them to examine whether GLP-1s might affect bone and other connective tissue more broadly.

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