A mathematical model that looks at different strategies for curbing hospital-acquired infections suggests that antimicrobial cycling and patient isolation may be effective approaches when patients are harboring dual-resistant bacteria. In an era of "superbugs," such as methicillin-resistant Staphylococcus aureas (MRSA), and an increasing public awareness and concern over bacterial infections, this type of modeling, if used to develop policies and treatment protocols, may reduce dual drug-resistant infections in hospitals.